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KMID : 1146920190490010149
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 1 p.149 ~ p.160
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Design, fabrication and characterization of xanthan gum/liquid-loaded porous natural rubber film
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Phaechamud Thawatchai
Lertsuphotvanit Nutdanai
Issarayungyuen Pongsathorn
Chantadee Takron
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Abstract
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Porous natural rubber (NR) films were prepared with blocked natural rubber by solvent casting method using dichloromethane as the solvent. The various amount of xanthan gum (0?40 phr) was blended in 75 phr triethyl citrate or glycerin-loaded NR cast films. Xanthan gum markedly promoted the water sorption of these composite films. The proper compatibility of the component employed in these composite NR films was confirmed by X-ray diffractometry, thermogravimetry and differential scanning calorimetry. Although the porosity of composite NR films decreased when xanthan gum was added xanthan gum amount did not significantly affect the mechanical properties, wettability and degradability. The 20 phr xanthan gum was selected as the optimum amount to modify the liquid-loaded NR films for further as wound dressing.
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KEYWORD
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Natural rubber, Xanthan gum, Liquid loading, Physicochemical characterization
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